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(A) Mean number of hot flushes per week and (B) mean daily frequency by intensity during treatment weeks 5, 13, and 23 with 40 mg of E4 or placebo in patients with prostate cancer treated with an LHRH agonist (per-protocol population). Severity was recorded as mild, moderate, severe, or very severe; very severe was not reported by any patient. E4 = estetrol; HF = hot flush; LHRH = luteinizing hormone–releasing hormone.
