Table 3.
Percentage change in laboratory parameters in comparison to baseline after 24 wk of treatment for the per-protocol population [12]
| Parameter | Percentage change, % (standard deviation) |
p value | |
|---|---|---|---|
| Estetrol (n = 37) |
Placebo (n = 20) |
||
| Prostate-specific antigen | −96.4 (5.3) | −83.1 (30.2) | 0.0033 |
| Total testosterone | −97.1 (1.6) | −97.4 (1.5) | 0.2819 |
| Free testosterone | −93.2 (4.0) | −89.7 (6.9) | 0.0389 |
| Luteinizing hormone | −97.6 (1.8) | −97.6 (2.8) | 0.6805 |
| Follicle-stimulating hormone | −97.8 (1.7) | −56.7 (44.8) | <0.0001 |
| Estradiol | −81.6 (10.5) | −82.3 (14.9) | 0.7639 |
| SHBG | +185.0 (111.4) | −2.5 (15.8) | <0.0001 |
| Dehydroepiandrosterone sulfate | −26.8 (18.9) | −26.8 (18.8) | 0.5875 |
| Osteocalcin | −22.0 (19.7) | +47.6 (47.2) | <0.0001 |
| CTX1 | −24.8 (34.6) | +151.1 (109.1) | <0.0001 |