Fig. 1.
DNA-PKcs deletion attenuates sepsis-induced myocardial damage. (A-C) Echocardiography was used to analyze myocardial function in control and DNA-PKcsCKO mice administered LPS. (D-F) ELISA was used to analyze the concentrations of LDH, CK-MB, and Troponin T in mouse serum. (G) Electron microscopy was used to assess myocardial ultrastructure. (H-K) Immunohistochemistry was used to detect the expression of IL-6 and MCP1 in myocardium after LPS treatment. (L-N) qPCR was applied to analyze the transcription of IL-6, TNFα, and MCP1 in cardiac tissue. *p < 0.05.