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Deletion of DNA-PKcs reduces sepsis-related liver dysfunction. (A-C) Serum levels of ALT, AST, and the AST/ALT ratio, were determined by ELISA in control and DNA-PKcsLKO mice administered LPS. (D-F) Immunofluorescence was applied to observe changes in MMP9 and VCAM1 expression in liver tissue. (G-I) qPCR was applied to analyze the transcription of IL-1, IL-6, and TNFα in hepatic tissue. *p < 0.05.
