KEY RESOURCES TABLE

REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
PML	Abcam	Cat# ab96051; RRID: AB_10679887
TRF2	Novus Biology	Cat# NB110-57130; RRID: AB_844199
G-quadruplex (BG4)	Millipore Sigma	Cat# MABE917; RRID: AB_2750936
G-quadruplex (1H6)	Millipore Sigma	Cat# MABE1126
S9.6	Millipore Sigma	Cat# MABE1095; RRID: AB_2861387
RAD52	Abcam	Cat# ab124971; RRID: AB_10971685
Biotin	Abcam	Cat# ab53494; RRID: AB_867860
GAPDH	Millipore	Cat# ABS16; RRID: AB_10806772
Ku80	NeoMarker	Cat# MS-285 P; RRID: AB_62299
RAD51AP1	Proteintech	Cat#11255-1-AP; RRID: AB_2300786
Chemicals, Peptides, and Recombinant Proteins
T4 Polynucleotide Kinase	NEB	M0201S
Proteinase K	Thermo Fischer	25530049
RNase H	NEB	M0297
RNase A	Millipore Sigma	R6513
CDK1i (RO-3306)	Selleckchem	S7747
BSA	NEB	B9000S
Click-iT EdU Alexa Fluor 488 Imaging Kit	Thermo Fischer	C10337
Formamide	Sigma	47671-1L-F
20x SSC	Invitrogen	AM9763
Azide-PEG3-Biotin	Sigma	762024-10MG
phi29 DNA Polymerase	NEB	M0269L
dNTP Set (100 mM)	Thermo Fischer	10297018
PureLink Genomic DNA Mini Kit	Thermo Fischer	K182002
ULTRAhyb hybridization buffer	Invitrogen	AM8669
LNA Control and LNA TERRA	Qiagen	Custom made
DRB	Millipore Sigma	D1916
Deposited data
Raw western blot and immunofluorescence data	This study	https://data.mendeley.com/datasets/vhz6phhb6c/draft?a=1e79524c-52e6-4716-a154-4a7d3885ecc7
Oligonucleotides
Oligos used in this study	This study	Table S1
Software and Algorithms
Fiji	ImageJ	https://imagej.net/software/fiji/
NIS element viewer	Nikon	https://www.nikoninstruments.com/Products/Software/NIS-Elements-Advanced-Research/NIS-Elements-Viewer
Image Lab	BioRad	http://www.bio-rad.com/en-us/product/image-lab-software
Image studio	Li-COR	https://www.licor.com/bio/image-studio/