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. 2022 Jul 4;30(11):3477–3498. doi: 10.1016/j.ymthe.2022.06.016

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CircSamd4 overexpression reduces oxidative injury and promotes CM proliferation in vivo

(A) Evaluation of adult CM proliferation by Ki67 immunostaining. CMs were isolated from adult mouse hearts 14 days after AAV9-circSamd4 or AAV9-NC injection. ∗p < 0.05, n = 6. (B) Evaluation of adult CM proliferation by pH3 immunostaining. ∗p < 0.05, n = 6. (C) Evaluation of adult CM proliferation by Anillin immunostaining. ∗p < 0.05, n = 6. (D) Detection of intracellular ROS levels in the myocardium 14 days after AAV9-circSamd4 or AAV9-NC injection; ∗p < 0.05, n = 6. (E) Detection of oxidative DNA damage in the adult myocardium 14 days after AAV9-circSamd4 or AAV9-NC injection; ∗p < 0.05, n = 6. (F) WGA staining of adult mouse hearts 14 days after AAV9-circSamd4 or AAV9-NC injection. (G) Detection of Ki67+ adult CMs in the peri-infarcted area 14 days post MI. Ki67+ CMs are indicated by arrows, ∗p < 0.05, n = 6. (H) Detection of pH3+ adult CMs in the peri-infarcted area 14 days post MI; ∗p < 0.05, n = 6. (I) Detection of intracellular ROS levels in the peri-infarcted area 14 days post MI; ∗p < 0.05, n = 6. (J) Detection of oxidative DNA damage in adult CMs 14 days post MI; ∗p < 0.05, n = 6.