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. 2022 Jul 4;30(11):3477–3498. doi: 10.1016/j.ymthe.2022.06.016

Figure 5.

Figure 5

CircSamd4 overexpression restores cardiac function after MI

(A) Evaluation of the left ventricular ejection fraction (LVEF), left ventricular end-systolic dimension (LVESD), left ventricular end-diastolic dimension (LVEDD), and fractional shortening (FS) post MI after circSamd4 overexpression. The echocardiography analysis was performed on days 1, 7, 14, and 28 after surgery. ∗p < 0.05 versus the sham group, #p < 0.05 versus the AAV9-NC group, and ampersand (&) indicates p < 0.05 versus the AAV9-Samd4 group, n = 6. (B) PET-CT of the adult mouse heart 28 days post MI; ∗p < 0.05 versus the AAV9-NC group, n = 6. (C) Masson trichrome staining of cross sections from adult mouse hearts at 28 days post MI. ∗p < 0.05 versus the AAV9-NC group, n = 6. (D) TTC staining of cross sections from adult mouse hearts at 28 days post MI. ∗p < 0.05 versus the AAV9-NC group, n = 6.