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. 2022 Jul 4;30(11):3477–3498. doi: 10.1016/j.ymthe.2022.06.016

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CircSamd4 downregulation increases oxidative injury and impairs regenerative repair in the neonatal mouse heart post MI

(A) Detection of intracellular ROS levels in the myocardium with dihydroethidium (DHE) 7 days post MI; ∗p < 0.05, n = 6. (B) Detection of oxidative DNA damage in neonatal CMs with 8-OHG staining 7 days post MI; ∗p < 0.05, n = 6. (C) In vivo evaluation of CM proliferation by Ki67 immunostaining 7 days post MI. Ki67+ CMs are indicated by arrows; ∗p < 0.05, n = 6. (D) In vivo evaluation of CM proliferation by pH3 immunostaining 7 days post MI. pH3+ CMs are indicated by arrows; ∗p < 0.05, n = 6. (E) Evaluation of left ventricular function 7 days post MI; ∗p < 0.05, n = 6. (F) Evaluation of the fibrotic area 7 days post MI; ∗p < 0.05, n = 6.