Figure 2.

Single-cell transcriptomic profiling of the tumor immune microenvironment upon BET inhibition

(A) UMAP plot showing identified cell populations from 2 merged groups that were treated with control and JQ1. (B) UMAP plot showing the expression of selected marker genes in the 7 clusters. (C) UMAP plot of the identified intratumoral infiltrating immune cells. (D) UMAP plot showing the expression of selected marker genes in immune cells. (E) Proportion of different subsets of immune cells in response to JQ1 treatment. (F) UMAP plot of T cells from merged conditions. (G) UMAP plot of selected markers in T cells from merged conditions. (H) Proportion of different T cell subpopulations in response to JQ1 treatment.