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. 2022 Oct 24;13:1008301. doi: 10.3389/fendo.2022.1008301

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Copyright © 2022 Gu, Zeng, Ma, Zhang, Liu, Guo, Ruan, Chi, Zheng and Gao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Integrated analysis of DNA methylation and transcriptome gene expression, and prediction of sensitivity of methylation phenotypes to immune checkpoint therapy. (A) Heatmap showing the association between DNA methylation and gene expression, presenting with an epigenetic silencing pattern. (B) Dotplot showing the Enrichr functional enrichment of 1,467 adjacent genes. (C) Heatmap of subclass analysis result showing the differences of sensitivity to several immune checkpoint inhibitors between the CIMP and nCIMP groups.