Figure 3.

JAZF1-SUZ12 decreases H3K27me3 and increases H4Kac at PRC2 target genes

(A) Metagene plots (above) and heatmaps (below) of H3K27me3 (left) and H4Kac (right) around sites shared by SUZ12, SUZ12Δ93, and JAZF1-SUZ12 in ESCs (n = 1,894) or EBs (n = 998) (averages of two independent ChIPs). In the heatmaps, occupancy (normalized reads) is indicated by color, according to the scales on the right. At each time point, sites are ordered by H3K27me3 in cells expressing SUZ12, from high to low.

(B) H3K27me3 and H4Kac (reads per 10-bp window) at the regions shown in Figure 2D in ESCs expressing SUZ12, SUZ12Δ93, or JAZF1-SUZ12 at days 0 and 8 during differentiation.

See also Figure S3.