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. 2022 Oct 24;13:1006434. doi: 10.3389/fimmu.2022.1006434

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Copyright © 2022 Chen, Peng, Xing, Chen, Peng and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview of the pathological course of neuroinflammation and the mechanisms of natural flavonoids against neuroinflammation. (A) Under neuroinflammation state, microglia and astrocytes are activated and secrete a lot of inflammatory cytokines, chemokines, along with small-molecule messengers which disturb the normal functioning of neurons and cause damage in brain tissue. (B) Natural flavonoids play anti-neuroinflammatory effects via inhibiting the activation of NLRP3 inflammasome and MAPKs, JAK/STAT, NF-κB pathways, promoting Nrf2, AMPK, BDNF/CREB, Wnt/β-Catenin, PI3k/Akt pathways and SIRT1-mediated HMGB1 deacetylation.