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. 2022 Aug 3;40(5):111162. doi: 10.1016/j.celrep.2022.111162

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© 2022 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Position on the group 3/group 4 continuum is linearly associated with isoform usage and non-synonymous RNA editing events

(A) Heatmap showing expression of top significantly differentially expressed isoforms of genes whose overall expression is otherwise not significantly differentially expressed with respect to G3/G4 score.

(B) Schematic showing exon structure of 4 GTF2I isoforms significantly differentially expressed with respect to G3/G4 score (left) and scatterplot showing expression of these GTF2I isoforms versus G3/G4 score; line represents fitted log-linear model NB: GTF2I is not significantly differentially expressed at the gene level.

(C) Top 10 significantly differentially edited non-synonymous RNA editing positions with respect to G3/G4 score.

(D) Boxplot showing level of T > C RNA editing at a non-synonymous position S367G within AZIN1 divided into highG4, lowG4, G3.5, lowG3, and highG3 (these categories are arbitrary divisions of the continuum for the purposes of visualization and comparison and do not represent “real” subgroups); level of editing is significantly associated with G3/G4 score.