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. 2022 Aug 3;40(5):111162. doi: 10.1016/j.celrep.2022.111162

Figure 5.

Figure 5

Distribution of single cells along the group 3/group 4 continuum is limited according to DNA methylation subtype

(A) Violin plot showing per-cell G3/G4 score (derived from projection onto scRNA-seq data) for 15 MBGrp3/MBGrp4 patients aggregated by subtype.

(B) Ridge plot showing distribution of per-cell G3/G4 score (derived from projection onto scRNA-seq data) for each of 15 MBGrp3/MBGrp4 patients shown alongside the G3/G4 score distribution of equivalent subtype bulk tumors. n = x refers to number of individuals for bulk tumors and number of cells for the scRNA-seq data. Vertical black lines indicate from left to right the fifth percentile, median, and 95th percentile. Dotted vertical lines denote the boundaries between highG4, lowG4, G3.5, lowG3, and highG3 (these categories are arbitrary divisions of the continuum for the purposes of visualization and comparison and do not represent “real” subgroups).