Table 2.
Univariable analysis of clinical variables.
| OS | PFS | |||||
|---|---|---|---|---|---|---|
| Covariate | HR (95% CI) | p-value | Global p-value | HR (95%CI) | p-value | Global p-value |
| Age (years) | 1.05 (1.00, 1.10) | 0.043 | 1.05 (1.01, 1.08) | 0.0046 | ||
| Sex | 1 | 0.19 | ||||
| Female | Reference | Reference | ||||
| Male | Not estimable | 2.64 (0.63, 11.11) | ||||
| ECOG PS | 0.074 | 0.33 | ||||
| ECOG 0 | Reference | Reference | ||||
| ECOG 1-2 | 2.70 (0.91, 8.04) | 1.46 (0.68, 3.12) | ||||
| Smoking pack year | 1.01 (0.98, 1.05) | 0.38 | 1.01 (0.99, 1.03) | 0.51 | ||
| History of Smoking | 0.92 | 0.67 | ||||
| Current | Reference | Reference | ||||
| Ex-smoker | 1.83 (0.34, 10.01) | 0.48 | 2.05 (0.63, 6.65) | 0.23 | ||
| Non-smoker | 1.40 (0.29, 6.74) | 0.67 | 1.46 (0.48, 4.45) | 0.5 | ||
| Unknown | Not estimable | 1 | 1.91 (0.21, 17.14) | 0.56 | ||
| Primary Pathology | 0.55 | 0.97 | ||||
| NPC, Type 1/2 (WHO I/IIA) | Reference | Reference | ||||
| NPC: Type 3 (WHO IIB) | 0.70 (0.22, 2.27) | 0.98 (0.42, 2.31) | ||||
| EBER | 0.37 | 0.095 | ||||
| Negative | Reference | Reference | ||||
| Positive | 0.50 (0.11, 2.29) | 0.44 (0.17, 1.16) | ||||
| EBV Titer pre RT | 1.00 (1.00, 1.00) | 0.59 | 1.00 (1.00, 1.00) | 0.59 | ||
| T stage 7th | 0.46 | 0.43 | ||||
| T1–2 | Reference | Reference | ||||
| T3 | 1.39 (0.35, 5.56) | 0.64 | 0.63 (0.24, 1.66) | 0.35 | ||
| T4 | 2.28 (0.61, 8.48) | 0.22 | 1.24 (0.53, 2.91) | 0.62 | ||
| N stage 7th | 0.75 | 0.93 | ||||
| N0 | Reference | Reference | ||||
| N1 | 0.43 (0.09, 2.11) | 0.3 | 1.52 (0.42, 5.54) | 0.52 | ||
| N2 | 0.69 (0.17, 2.78) | 0.61 | 1.44 (0.41, 5.12) | 0.57 | ||
| N3 | 0.46 (0.05, 4.45) | 0.5 | 1.59 (0.32, 7.87) | 0.57 | ||
| Overall Stage 7th | 0.27 | 0.18 | ||||
| I-III | Reference | Reference | ||||
| IV | 1.85 (0.62, 5.50) | 1.67 (0.79, 3.54) | ||||
| RT/CRT Regimen | 0.32 | 0.035 | ||||
| CCRT - RT | Reference | Reference | ||||
| CCRT+AC - IC+CCRT | 0.58 (0.19, 1.72) | 0.45 (0.21, 0.95) | ||||