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. 2022 Oct 24;12:951560. doi: 10.3389/fonc.2022.951560

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Copyright © 2022 Lee, Yang, Lin, Hsieh, Chen, Chang, Lin and Liao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A hybrid intelligence model was developed to integrate human decision-making in clinical pathology with data extracted by the Domain-KEY algorithm. Two pathologists checked the correctness (orange background) of all Domain-KEY-labeled (blue background) whole-slide images (A). The review was implemented after the integration of the Domain-KEY AI algorithm into an open-source software (MetaLite). Green and blue rectangles denote Domain-KEY-labeled areas of perineural invasion and normal nerve fibers, respectively (B).