Table 2.
Changes in Hemodynamics and Clinical Parameters of Patients in the Total Cohort
| Median difference | Study entry | Final follow-up | P value | |
|---|---|---|---|---|
| Mean PAP (mmHg) | −6 [−14, 1] | 38 [32, 44] | 32 [26, 39] | <0.001 |
| PAWP (mmHg) | 1 [−3, 3] | 9 [7, 11] | 10 [7, 12] | 0.56 |
| Mean RAP (mmHg) | 0 [−3, 2] | 5 [4, 8] | 6 [4, 8] | 0.70 |
| PVR (dyn·s·cm−5) | −191 [−336, −34] | 465 [326, 587] | 264 [189, 372] | <0.001 |
| Cardiac index (L/min/m2) | 0.60 [−0.38, 1.53] | 3.00 [2.47, 3.80] | 3.90 [3.20, 4.50] | 0.039 |
| SvO2 (%) | 1 [−2, 7] | 75 [68, 75] | 74 [71, 77] | 0.071 |
| 6MWD | 25 [3, 68] | 380 [308, 455] | 410 [349, 480] | 0.039 |
| BNP (pg/mL) | −15 [−146, 15] | 60 [21, 209] | 40 [24, 72] | 0.039 |
| WHO functional class | 0.044 | |||
| I | – | 6 (9.7) | 10 (17.9) | – |
| II | – | 28 (45.2) | 29 (51.8) | – |
| III | – | 25 (40.3) | 16 (28.6) | – |
| IV | – | 3 (4.8) | 1 (1.8) | – |
Unless indicated otherwise, values are expressed as the median [interquartile range] or n (%). PAP, pulmonary artery pressure; PAWP, pulmonary artery wedge pressure; PVR, pulmonary vascular resistance; RAP, right arterial pressure; SvO2, mixed venous oxygen saturation. Other abbreviations as in Table 1.