Table 1.

Functional and Electrophysiological Similarities Between Astrocytes, SVZ Neural Stem Cells, and Radial glia.

Astrocytes	SVZ NSCs	Radial glia	Citations
Functional gap junction coupling; express connexin 43 and exhibit dye coupling	Functional gap junction coupling; express connexin 43 and exhibit dye coupling	Functional gap junction coupling; express connexin 43 and exhibit dye coupling	(Beckervordersandforth et al., 2010; Dulken et al., 2017; Liu et al., 2006)
Inward/outward currents—linear current–voltage curve	Inward/outward currents—linear current–voltage curve	Voltage-dependent outward currents	(Liu et al., 2006)
KIR4.1/2.1 key in K+ buffering, present in SLC1A3+ cells	KIR4.1/2.1 present in SLC1A3+ cells	Unknown	(Liu et al., 2006)
High levels of SLC1A2, lower levels of SLC1A3	High levels of SLC1A3 and lower levels of SLC1A2	Express SLC1A3 only	(Beckervordersandforth et al., 2010; Furuta et al., 1997; Kugler and Schleyer, 2004; Liu et al., 2006)
GFAP intermediate filament protein expression varies	GFAP intermediate filament protein positive	Variable levels of GFAP intermediate filament protein depending upon species	(Doetsch et al., 1999a; Liu et al., 2006)
Express ALDH1L1. Catalyzes conversion of NADP+ to NADPH+	Express ALDH1L1. Catalyzes conversion of NADP+ to NADPH+	Express ALDH1L1. Catalyzes conversion of NADP+ to NADPH+	(Beyer et al., 2021; Tien et al., 2012)

Note. SVZ = subventricular zone; NSC = neural stem cell; NADP = nicotinamide-adenine-dinucleotide phosphate; NADPH = nicotinamide adenine dinucleotide phosphate; GFAP = glial fibrillary acidic protein; ALDH1L1 = aldehyde dehydrogenase 1 family member L1.