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. 2022 Oct 18;42(13):1359–1374. doi: 10.1177/03331024221110111

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© International Headache Society 2022

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — Effect of VTA^PBP pharmacological modulation on neuronal firing in the trigeminocervical complex (TCC), in response to mechanical stimulation of the ophthalmic dermatome (V1).

Time course changes in the average response of TCC neurons to somatosensory-evoked stimulation of the cutaneous facial receptive field. (a) response to innocuous brush stimulation following microinjection of naratriptan (n = 8), PACAP38 (n = 7) and quinpirole (n = 8) into the VTA^PBP; (b) response to noxious pinch stimulation following microinjection of glutamate (n = 7) and bicuculline (n = 4) into the VTA^PBP; and (c) response to noxious pinch stimulation following microinjection of naratriptan (n = 8), PACAP38 (n = 7) and quinpirole (n = 8) into the VTA^PBP. In all panels vehicle control (n = 11) had no significant effects of neuronal responses. Data have been normalized to represent the percentage change from baseline, and are expressed as means ± SEM. *p < 0.05; **p < 0.01.