Figure 6.

Glucose homeostasis in middle-aged male IGF1R-deficient mice. Serum levels of glucose (A) and insulin (B); and insulin resistance index (HOMA) (C) in CreERT2 IGF1R-deficient middle-aged male and female mice compared to their Igf1r^fl/fl counterparts and to young (13 weeks-old) Igf1r^fl/fl on STD. Data are expressed as mean ± SEM of at least 4 animals per group (n= 4-11 mice per group). ^ap < 0.05, ^aa p < 0.01 and ^aaap < 0.001 vs. young Igf1r^fl/fl STD mice. *p < 0.05, **p < 0.01 vs. middle-aged Igf1r^fl/f STD animals; ^##p < 0.01 vs. middle-aged Igf1r^fl/fl HFD mice; and ^$ p < 0.05 vs. middle-aged CreERT2 STD animals.