Figure 2.

Substrate location and pattern interaction with Sis0455. (A) 2Fo – Fc map at the substrate binding pocket superimposed onto its corresponding refined structure. Map displayed at 2.0 σ contour value. (B) Fo – Fc omit map at the substrate binding pocket superimposed onto its corresponding cA₄ non-processed structure. FoFc omit map is displayed at 4.0 σ contour value. (C) Zoom view at the substrate binding pocket within the dimer Sis0455 in complex with its substrate, depicting their key interacting residues. (D) Zoom view at the key residues involved in stabilizing the closed dimer state, caging the substrate.