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Chromosomal DSBs repaired in cells expressing K273A Lig4 have characteristics of a-EJ. (A) Diagram of region on chromosome nine targeted by two different gRNAs and position of primers utilized to detect chromosomal deletions induced by Cas9 and indicated gRNAs. (B) Summary of amplicon analyses of PCR amplified deletional joints from indicated cell strains. (C) Histograms depicting numbers of nucleotides deleted, inserted, or extent of microhomology at site of joining.
