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. 2022 Oct 16;50(19):10857–10868. doi: 10.1093/nar/gkac897

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© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — X-ray crystal structure of a complex formed between ADAR2-R2D E488Q and a 32 bp 8-azanebularine (azaN) containing duplex with G:3-deaza dA pair (32 bp G3A RNA) adjacent to azaN. (A) Fit of a G_syn:3-deaza dA_anti base pair in the 2F_o– F_c electron density map contoured at 1σ. (B) Overlay of ADAR2 R2D E488Q structures with RNA bearing either 5′ G paired with G (salmon colored carbons) or 5′ G paired with 3-deaza dA (green colored carbons). Arg455 in both structures is identical and shown with white-colored carbons. (C) The G_syn:3-deaza dAH+_anti pair (28). (D) Overlay of ADAR2 R2D E488Q structures with RNA bearing either 5′ U paired with A (cyan colred carbons) or 5′ G paired with 3-deaza dA (green colored carbons).