Table 4.

Rate constants for in vitro deamination for 100 nM ADAR2 acting on 10 nM substrate bearing nucleoside analogs paired with 5′ G (X position). X = guanosine (G), adenosine (A), 2′-deoxyguanosine (dG), 2′-deoxyadenosine (dA), 7-deaza-2′-deoxyguanosine (7-deaza dG), 8-bromo-2′-deoxyguanosine (8-bromo dG) and 3-deaza-2′-deoxyadenosine (3-deaza dA). ^aData were fitted to the equation [P]_t = [P]_f[1 – exp(–k_obs·t)]. ^bk_rel = k_obs for different nucleosides at X position/k_obs for X = G