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. 2022 Oct 27;50(19):11285–11300. doi: 10.1093/nar/gkac934

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© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — Cryo-EM structure of the L. monocytogenes lincomycin-70S complex. (A) Chemical structure of lincomycin, with galactopyranosyl (orange), methylsulfanyl (yellow), hydroxypropyl (green), carboxamide (blue) and propylpyrrolidine (cyan) moieties highlighted. (B) Cryo-EM density (mesh) with molecular model of lincomycin (Lnc, blue). (C) Molecular model of Lnc (blue) with cryo-EM density (mesh) and model for waters W1-W4 (red). (D) Cryo-EM density of L. monocytogenes Lnc-70S complex with Lnc bound at the PTC, adjacent to the ribosomal NPET in the 50S (grey) subunit. (E) Lnc (blue) with surrounding waters W1-W4 (red) and 23S rRNA nucleotides (grey). (F) Water-mediated interaction of the hydroxypropyl-group of Lnc (blue) with N2 of G2094 (EcoG2061, grey) through W1 (red) and N7 of A2536 (EcoA2503, grey) through W2 (red). (G) Water-mediated interaction of Lnc (blue) with N1 of A2091 (EcoA2058, grey) and W3 and N4 of C2644 (EcoC2611, grey) with W4 (red).