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Overexpression of miR-22-3p and miR-29a-3p synergistically induce cellular senescence. (a) The function of these two miRNAs mimics on cellular senescence was detected by SA-β-gal staining analysis. Scale bars = 200 μm. (b) The p16 and p21 expressions were examined by co-IF (p16: green, p21: red, nuclear: blue; 200 ×, scale bars = 50 μm). (A color version of this figure is available in the online journal.)
