Table 2:

Significant Between Network Connectivity in BMI-discordant Twins (n=94) and Unrelated, BMI-Discordant Pairs (n=94)

BMI-Discordant Twins
Contrast	IC	Network	T-value	p _FWE
Higher BMI > Lower BMI	9	Occipital pole	4.30	0.004
	2	Default Mode Network	4.30	0.004

	16	Right crus I	3.64	0.037
	7	Insula, central operculum, precentral gyrus, and anterior cingulate	3.64	0.037

	10	Dorsolateral prefrontal cortex, ventrolateral prefrontal cortex	4.57	0.001
	22	Left crus II	4.57	0.001

Lower BMI > Higher BMI	9	Occipital pole	4.04	0.003
	3	Occipital pole, intracalcarine cortex, and lingual gyrus	4.04	0.003

	9	Occipital pole	4.19	0.005
	7	Insula, central operculum, precentral gyrus, and anterior cingulate	4.19	0.005

	10	Dorsolateral prefrontal cortex, ventrolateral prefrontal cortex	3.70	0.035
	25	Dorsal striatum, ventral striatum, insula	3.70	0.035

Unrelated, BMI-Discordant Pairs
Contrast	IC	Network	T-value	p _FWE

Higher BMI > Lower BMI	2	Default Mode Network	4.71	0.002
	7	Insula, parietal operculum, and dorsal anterior cingulate cortex	4.71	0.002

	4	Lateral occipital cortex	4.62	0.003
	12	Lingual gyrus, occipital cortex	4.62	0.003