Scheme 4. Substrate Scope for the Synthesis of Isoindolin-2-yl-acetamides,,

Reaction conditions: 1 (0.3 mmol), 4 (0.45 mmol), K₂CO₃ (0.6 mmol), CuBr (0.06 mmol), PEG-400 (2 mL), 100 °C, 2 h.

Yield refers to the purified products through a single step.

E/Z was calculated based on ¹H NMR.