FIGURE 1.

Administration of MOTS‐c peptide prevented cardiac dysfunction in TAC‐induced HF mice. (A) Schematic image of the experimental design. (B) Representative echocardiograms showing short‐axis M‐mode 2D echocardiography performed at the end of the animal experiment. (C) LVEF at different time points post‐TAC. (D) LVIDd at different time points post‐TAC. LVEF, left ventricular ejection fraction; LVIDd, left ventricular internal diameter during diastole; TAC, transverse aortic constriction. Data are represented as the mean ± SEM, n = 6 in each group. *p < 0.05; **p < 0.01