Table 1.
Characteristics and comorbidities of Streptococcus pneumoniae-infected and non-infected patients
| CHD | HF | Stroke | AF | |||||
| Non-infected | Infected | Non-infected | Infected | Non-infected | Infected | Non-infected | Infected | |
| N | 43 499 | 209 | 44 148 | 179 | 44 768 | 221 | 39 568 | 241 |
| Cardiovascular event incidence | 2090 (4.8%) | 12 (5.7%) | 3790 (8.6%) | 19 (11%) | 2502 (5.6%) | 24 (11%) | 703 (1.8%) | 12 (5.0%) |
| Age, mean (y) | 77.0 | 77.1 | 75.4 | 75.6 | 77.5 | 77.7 | 77.5 | 77.7 |
| Men | 22 062 (51%) | 106 (51%) | 24 417 (55%) | 99 (55%) | 22 890 (51%) | 113 (51%) | 20 523 (52%) | 125 (52%) |
| Women | 21 437 (49%) | 103 (49%) | 19 731 (45%) | 80 (45%) | 21 878 (49%) | 108 (49%) | 19 045 (48%) | 116 (48%) |
| Hospital admission | 30 595 (70%) | 147 (70%) | 29 103 (66%) | 118 (66%) | 31 804 (71%) | 157 (71%) | 29 224 (74%) | 178 (74%) |
| Myocardial infarction | 0 (0%) | 0 (0%) | 247 (0.6%) | 1 (0.6%) | 203 (0.5%) | 1 (0.5%) | 164 (0.4%) | 1 (0.4%) |
| Congestive heart failure | 4787 (11%) | 23 (11%) | 987 (2.2%) | 4 (2.2%) | 4051 (9.0%) | 20 (9.0%) | 4433 (11%) | 27 (11%) |
| Peripheral vascular disease | 1249 (2.9%) | 6 (2.9%) | 1233 (2.8%) | 5 (2.8%) | 1418 (3.2%) | 7 (3.2%) | 1149 (2.9%) | 7 (2.9%) |
| Cerebrovascular disease | 6036 (14%) | 29 (14%) | 5179 (12%) | 21 (12%) | 4254 (9.5%) | 21 (9.5%) | 5254 (13%) | 32 (13%) |
| Dementia | 6244 (14%) | 30 (14%) | 4933 (11%) | 20 (11%) | 5267 (12%) | 26 (12%) | 4761 (12%) | 29 (12%) |
| Chronic pulmonary disease | 12 488 (29%) | 60 (29%) | 14 305 (32%) | 58 (32%) | 12 762 (29%) | 63 (29%) | 11 000 (28%) | 67 (28%) |
| Rheumatic disease | 624 (1.4%) | 3 (1.4%) | 1233 (2.8%) | 5 (2.8%) | 810 (1.8%) | 4 (1.8%) | 985 (2.5%) | 6 (2.5%) |
| Peptic ulcer disease | 2914 (6.7%) | 14 (6.7%) | 3453 (7.8%) | 14 (7.8%) | 2633 (5.9%) | 13 (5.9%) | 2134 (5.4%) | 13 (5.4%) |
| Mild liver disease | 6868 (16%) | 33 (16%) | 7399 (17%) | 30 (17%) | 6685 (15%) | 33 (15%) | 4925 (12%) | 30 (12%) |
| Diabetes without chronic complications | 624 (1.4%) | 3 (1.4%) | 493 (1.1%) | 2 (1.1%) | 405 (0.9%) | 2 (0.9%) | 328 (0.8%) | 2 (0.8%) |
| Diabetes with chronic complications | 1249 (2.9%) | 6 (2.9%) | 1726 (3.9%) | 7 (3.9%) | 1215 (2.7%) | 6 (2.7%) | 1149 (2.9%) | 7 (2.9%) |
| Haemiplegia or paraplegia | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| Renal disease | 416 (1.0%) | 2 (1.0%) | 493 (1.1%) | 2 (1.1%) | 810 (1.8%) | 4 (1.8%) | 657 (1.7%) | 4 (1.7%) |
| Malignancy | 3538 (8.1%) | 17 (8.1%) | 4686 (11%) | 19 (11%) | 4051 (9.0%) | 20 (9.0%) | 3284 (8.3%) | 20 (8.3%) |
| Moderate or severe liver disease | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| Metastatic solid tumour | 833 (1.9%) | 4 (1.9%) | 987 (2.2%) | 4 (2.2%) | 608 (1.4%) | 3 (1.4%) | 657 (1.7%) | 4 (1.7%) |
| HIV/AIDS | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| AF | 328 (0.8%) | 2 (0.8%) | ||||||
Values are presented as number (percentage) unless stated otherwise.
AF, atrial fibrillation; CHD, coronary heart disease; HF, heart failure.