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. 2022 Nov 3;8(2):e002477. doi: 10.1136/rmdopen-2022-002477

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Flow diagram. *Matching criteria: age at diagnosis, gender, subtype (limited/diffuse), baseline modified Rodnan skin score, baseline FVC, baseline diffusing capacity of the lung for carbon monoxide, co-therapy immunosuppressive disease-modifying antirheumatic drugs (either one of prednisone >10 mg/day, methotrexate, azathioprine and mycophenolate mofetil), rituximab (biologic) within 6 months before baseline, disease duration (years), year of treatment. TCZ, tocilizumab; EUSTAR, European Scleroderma Trial and Research.