Table 1. Hallmarks of cancer.

Cancer hallmarks	Therapeutic targeting
Evading growth suppressors	Cyclin-dependant kinase inhibitors
Sustaining proliferative signalling	EGFR inhibitors
Resisting cell death	Pro-apoptotic BH3 mimetics
Enabling replicative immortality	Telomerase inhibitors
Inducing angiogenesis	Inhibitors of VEGF signalling
Avoiding immune destruction	Immune activating anti-CTLA4 monoclonal antibody
Tumour promoting inflammation	Selective anti-inflammatory drugs
Genome instability and mutation	PARP inhibitors
Deregulating cellular energetics	Aerobic glycolysis inhibitors
Activating invasion and metastasis	Inhibitors of HGF/c-Met

EGFR: epithelial growth factor receptor; VEGF: vascular endothelial growth factor; CTLA4: cytotoxic T lymphocyte-associated antigen 4; PARP: poly ADP-ribose polymerase; HGF: hepatocyte growth factor.