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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: Nat Struct Mol Biol. 2022 Sep 12;29(10):962–965. doi: 10.1038/s41594-022-00833-4

Fig. 2. Solvent-exposed amino acid residues at the top and bottom ends of huPrP23–144 fibrils.

Fig. 2

At the top end of the fibril, two clusters of hydrophobic residues (M112/A116/A117 and A120/V122) in protofilaments B and C (yellow and orange, a) or protofilaments A and D (pink and blue, b) are exposed to the solvent. At the bottom end of the fibril, two clusters of hydrophobic residues (M129/A133 and I139/F141) in protofilaments A and D (pink and blue, c) or protofilaments B and C (yellow and orange, d) are exposed to the solvent.