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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: Nat Struct Mol Biol. 2022 Sep 12;29(10):962–965. doi: 10.1038/s41594-022-00833-4

Extended Data Fig. 3. Non-planar architecture of two representative huPrP23–144 protofilaments assembled through large hydrophobic interfaces.

Extended Data Fig. 3

Subunit n in protofilament A interacts with two subunits in protofilament B (subunits m and m+1); subunit m+1 in protofilament B interacts with two subunits in protofilament A (subunits n and n+1). Such a non-planar conformation results in rugged surfaces at fibril ends, with N-terminal residues at the top end and C-terminal residues at the bottom end exposed to water. A similar non-planar assembly is observed for subunits in protofilaments C and D.