Skip to main content
. 2022 Nov 7;14:166. doi: 10.1186/s13195-022-01105-5

Table 2.

Sample size estimation to detect simulated intervention effects of 20%, 30%, and 40% in AD-spectrum patients. The model for the tau-PET-informed personalized cognitive composites was controlled for age, sex, clinical status, and APOE4 status

Required n per arm to detect an intervention effect
Intervention effect Episodic memory Standard global cognitive composite Personalized global cognitive composite
ADNI (N = 140)
 20% 461 168 123
 30% 198 69 51
 40% 109 36 27
A05 (N = 65)
 20% 261 279 239
 30% 114 115 98
 40% 63 60 52