Table 3.

Measurement timepoints of study objectives

Study Objectives		Measurement Timepoints
Objective Type	Objective Summary	Baseline (Y0)	Y1	Y2	Y3	Passive Follow-Up (Y4-Y7)
Objective 1 (Primary)	To evaluate the specificity of FIT for the detection of CRC and AA’s in patients with LS.	x	x	x	x
Objective 2 (Secondary a)	To identify and explore acceptability, views, and preferences of FIT in this patient population	x
Objective 3 (Secondary b)	To evaluate the sensitivity of FIT for the detection of CRC in patients with LS	x	x	x	x
Objective 4 (Secondary c)	To evaluate the sensitivity of FIT for the detection of AA’s in patients with LS	x	x	x	x
Objective 5 (Exploratory)	To examine and characterise the faecal microbiome of patients with LS.	x	x	x	x
Objective 6 (Exploratory)	To observe the incidence of interval CRCs for LS patients with FIT negative results (< 6 μg/g f-Hb)					xa

^aThis outcome will be measured in a subset of study participants