TABLE 1.
Agreement for detection of human papillomavirus overall and HPV types grouped according to the Xpert HPV assay between Xpert HPV assay and AmpFire HPV genotyping assay, Rwanda, June 2018 - June 2019.
| HPV results AmpFire/Xpert | +/+ |
−/+ |
+/− |
−/− |
Positive agreement (%) | Negative agreement (%) | Overall agreement (%) | Exact p-value for asymmetry | Unweighted kappa | 95% confidence interval | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | % | n | % | n | % | n | % | |||||||
| HPV16 | 35 | 12.4 | 1 | 0.4 | 18 | 6.4 | 229 | 80.9 | 65 | 92 | 93 | < 0.001 | 0.75 | 0.64–0.85 |
| HPV18/45 | 27 | 9.5 | 3 | 1.1 | 6 | 2.1 | 247 | 87.3 | 75 | 96 | 97 | 0.510 | 0.84 | 0.74–0.94 |
| HPV31/33/35/52/58 | 66 | 23.3 | 10 | 3.5 | 12 | 4.2 | 195 | 68.9 | 75 | 90 | 92 | 0.830 | 0.80 | 0.72–0.88 |
| HPV51/59 | 13 | 4.6 | 1 | 0.4 | 6 | 2.1 | 263 | 92.9 | 65 | 97 | 98 | 0.130 | 0.77 | 0.61–0.94 |
| HPV39/56/66/68 | 23 | 8.1 | 6 | 2.1 | 12 | 4.2 | 242 | 85.5 | 56 | 93 | 94 | 0.240 | 0.68 | 0.55–0.82 |
| HR13† + HPV 66 | 134 | 47.3 | 10 | 3.5 | 22 | 7.8 | 117 | 41.3 | 81 | 79 | 89 | 0.050 | 0.77 | 0.70–0.85 |
Note: N = 283 women living with HIV undergoing colposcopy (non-hierarchical).
HPV, human papillomavirus.
†
, HR13 includes HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68.