Figure 3.

Radiographic evaluation of ONC201 in pediatric patients with H3 K27M-mutant thalamic glioma (a, b) or DIPG (c, d) who had previously received radiation. (a) Sagittal T1 post-contrast MRI images and (b) tumor size in enrolled patient prior to and following ONC201 treatment. Baseline MRI is 2 days after completion of radiation and ONC201 treatment began 7 days after completion of radiation. (c) Sagittal T1 post-contrast and T2/FLAIR MRI images of the primary tumor at baseline and at 19, 36, 52, and 60 weeks after beginning ONC201 treatment of a 9-year-old male with DIPG who began ONC201 4.5 weeks after completing radiation therapy and (d) radiographic change in tumor burden from baseline.