Table 3.
Pharmacokinetic parameters of ONC201 after the first dose (N = 22)
| Parameter | Mean | SD | Median | Minimum | Maximum |
|---|---|---|---|---|---|
| C max (µg/mL) | 2.3 | 1.3 | 1.9 | 0.9 | 6.8 |
| T max (h) | 2.1 | 1.25 | 2 | 0.5 | 4 |
| AUC0-tlast (µgh/mL) | 16.4 | 8.3 | 14.7 | 5.3 | 34.9 |
| AUC0-inf (µgh/mL) | 16.5 | 9.4 | 13.6 | 5.3 | 35.8 |
| T1/2 (h) | 8.37 | 6.19 | 6.26 | 2.89 | 24.5 |
| CL (L/h) | 27.5 | 12.7 | 23.9 | 7.58 | 52.8 |
| Vd (L) | 187 | 138 | 140 | 64.4 | 546 |
AUC0-inf, area under the curve from time 0 to infinity; AUC0-tlast, area under curve from time 0 to last time point with measurable concentration; CL, clearance; Cmax, maximum serum concentration; SD, standard deviation; T1/2, half-life; Tmax, time to Cmax; Vd, volumne of distribution.