Wound healing performance of the hydrogel in a full-thickness skin defect model. (a) Wounds images in rats after being treated with PBS, DEX/GO hydrogel (DEX/GO0), DEX/GO5 hydrogel scaffold (DEX/GO5), DEX/GO5 hydrogel scaffold loaded with VEGF but without NIR irradiation (DEX/GO5/VEGF-NIR), and DEX/GO5 hydrogel scaffold loaded with VEGF and meanwhile irradiated using NIR for 5 min (1 W/cm2) (DEX/GO5/VEGF+NIR). (b) Quantitative analysis of wound areas of each group (n = 6). (c) The quantitative width of wound edges of each group. (d) H&E staining of wound tissues after being treated for 11 days. The below columns are the magnified image of the corresponding top column (The red arrows indicated microscopic wound edges). Scale bars are 400 μm (top) and 100 μm (below), respectively.