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. 2022 Nov 4;11(1):2670–2679. doi: 10.1080/22221751.2022.2135460

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Response to vaccination. In (A) individual profiles of HAI antibody responses at day 28 against Wt H1 and modified viruses H1-ΔSb, H1-ΔSa, H1-ΔCb and H1-ΔCa1 and H1-ΔCa2 is represented. GMT value is marked in each column. P-values were determined with the repeated measures one-way Bonferroni’s ANOVA for multiple comparisons test with the Geisser–Greenhouse correction; *P < .05, **P < .01, ***P < .001, ****P < .0001. In (B) SPR after vaccination was calculated as the percentage of patients that achieved HAI titres ≥ 1/40 for each virus and compared to the respective Wt H1 for each cohort. The two-tailed P-value was calculated with the McNemar’s test with the continuity correction; *P < .05, **P < .01, ***P < .001, ****P < .0001. In (C) Fold induction of HAI titres or GMT increase (calculated as “GMTpost/GMTpre”) is represented of modified viruses H1-ΔSb, H1-ΔSa, H1-ΔCb and H1-ΔCa1 and H1-ΔCa2 compared to the Wt H1 in each cohort. P-values were determined with the repeated measures one-way Bonferroni’s ANOVA for multiple comparisons test with the Geisser–Greenhouse correction; *P < .05, **P < .01, ***P < .001, ****P < .0001. In (D) SCR was calculated as percentage of patients who reached a four-fold-induction for each virus and compared to its respective Wt H1 for each cohort. The two-tailed P-value was calculated with the McNemar’s test with the continuity correction; *P < .05, **P < .01, ***P < .001, ****P < .0001.