Table 3.
Frequency of positive/negative anti-PGL-I levels in multibacillary leprosy patients and healthy contacts. Parameters of OR, diagnostic sensitivity and specificity, and negative and positive predictive values (and 95% interval confidence) for isolated anti-PGL- I IgA, IgM, IgG, IgM + one or more isotypes, and IgG + IgA antibody levels.
| Serum anti-PGL1 |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| IgM |
IgG |
IgA |
IgM + one or more isotypes |
IgG + IgA |
||||||
| Index cases (n = 50) |
Healthy contacts (n = 340) |
Index cases (n = 50) |
Healthy contacts (n = 340) |
Index cases (n = 50) |
Healthy contacts (n = 340) |
Index cases (n = 50) |
Healthy contacts (n = 340) |
Index cases (n = 50) |
Healthy contacts (n = 340) |
|
| Positive | 38 | 116 | 15 | 39 | 27 | 22 | 27 | 18 | 12 | 6 |
| Negative | 12 | 224 | 35 | 301 | 23 | 318 | 23 | 322 | 38 | 334 |
| Fisher test | p < 0.0001 | p = 0.0014 | p < 0.0001 | p < 0.0001 | p < 0.0001 | |||||
|
Odds ratio (95% CI) |
6.11 (3.08–12.16) |
3.31 (1.66–6.61) |
16.97 (8.39–34.2) |
21.0 (10.11–43.64) |
17.58 (6.23–49.54) |
|||||
| Diagnostic sensitivity (95% CI) | 76.0 (61.8–86.9) |
30.0 (17.8–44.6) |
54.0 (39.3–68.2) |
54.0 (39.3–68.2) |
24.0 (13.0–38.2) |
|||||
|
Diagnostic specificity (95% CI) |
65.9 (60.6–70.9) |
88.5 (84.7–91.7) |
93.5 (90.4–95.9) |
94.7 (91.8–96.8) |
98.2 (96.2–99.4) |
|||||
|
Positive predictive value (95% CI) |
24.7 (18.1–32.3) |
27.8 (16.5–41.6) |
55.1 (40.2–69.3) |
60.0 (44.3–74.3) |
66.7 (41.0–86.7) |
|||||
|
Negative predictive value (95% CI) |
94.9 (91.3–97.4) |
89.6 (85.8–92.6) |
93.3 (90.0–95.7) |
93.3 (90.2–95.7) |
89.8 (86.3–92.7) |
|||||
CI = confidence interval.