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. Author manuscript; available in PMC: 2022 Nov 7.

Published in final edited form as: AAPS J. 2021 Dec 1;24(1):5. doi: 10.1208/s12248-021-00656-z

Table I.

Comparison of Kochak-Benet (Eq. 4, Numerator) and Classical PTM (Eq. 2, Denominator) Equations for Hepatic Clearance (CL_H)

CL_int,PTM	Assigned values of Q_H
CL_int,PTM	300	600	900	1200	1500
→ 0	CL_int,PTM	CL_int,PTM	CL_int,PTM	CL_int,PTM	CL_int,PTM
300	300/190	300/236	300/255	300/265	300/272
600	600/259	600/379	600/438	600/472	600/495
900	900/285	900/466	900/569	900/633	900/677
1200	1200/295	1200/519	1200/663	1200/759	1200/826
1500	1500/298	1500/551	1500/730	1500/856	1500/948
3000	3000/300	3000/596	3000/868	3000/1101	3000/1297
6000	6000/300	6000/600	6000/899	6000/1192	6000/1470

Numbers have arbitrary values with units of volume/time