Figure 3.

Residual enzymatic OTC activity predicts number of HAE per year. (A) Number of HAE (NH₄ ⁺ _max ≥ 100 μmol/L) per year of observation subject to residual enzymatic OTC activity (%). Each point represents a single patient (n = 52). The grey line displays the estimated regression curve. GAM‐analysis, p = 0.04, R ² = 0.06. (B) Boxplot illustrating number of HAE (NH₄ ⁺ _max ≥ 100 μmol/L) per year of observation with residual enzymatic OTC activity below or equal to 16.0% (n = 35) or above 16.0% (n = 17). Data are shown as median (black thick line) and mean (triangle), length of the box corresponds to IQR and upper and lower whiskers correspond to the max. of 1.5 × IQR, each point represents an outlier. Recursive partitioning, p = 0.04.