Table 4.
Mixed model for the global cognitive composite in the limited dataset (≤6 years of follow‐up) as predicted by CSF NfL. Age was standardized. CSF NfL was transformed with the natural logarithm and then standardized.
| Predictors | Estimates | Std. Error | df | CI | p |
|---|---|---|---|---|---|
| (Intercept) | −0.836 | 0.207 | 370.819 | −1.242 to −0.429 | <0.001 |
| Age [Years] | −0.189 | 0.034 | 370.167 | −0.255 to −0.122 | <0.001 |
| Education [Years] | 0.050 | 0.012 | 370.904 | 0.027 to 0.074 | <0.001 |
| Race [Black] | −0.581 | 0.107 | 375.046 | −0.791 to −0.370 | <0.001 |
| APOE ε4 status (ε4 carrier) | −0.020 | 0.063 | 371.166 | −0.145 to 0.105 | 0.754 |
| Sex [Female] | 0.238 | 0.064 | 371.535 | 0.112 to 0.364 | <0.001 |
| Time | −0.021 | 0.006 | 251.864 | −0.033 to −0.009 | 0.001 |
| CSF NfL | −0.080 | 0.035 | 369.351 | −0.150 to −0.011 | 0.023 |
| Time * CSF NfL | −0.024 | 0.006 | 255.508 | −0.036 to −0.012 | <0.001 |
| Random effects | |||||
| σ2 | 0.06 | ||||
| τ00 id | 0.30 | ||||
| τ11 id.time | 0.01 | ||||
| ρ01 id | 0.18 | ||||
| ICC | 0.86 | ||||
| N id | 371 | ||||
| Observations | 1637 | ||||
| Marginal R2/Conditional R2 | 0.207/0.889 | ||||