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Mlh1-Pms1 interface mutants are proficient for Msh2-Msh6-independent endonuclease function. A. PCNA/RFC-dependent, Msh2-Msh6-independent nicking of a supercoiled plasmid by Mlh1-Pms1 is followed by formation of a more slowly migrating nicked circular plasmid. B. Quantification shows that efficient nicking depends on Mlh1-Pms1 and PCNA and RFC, which activate the Mlh1-Pms1 endonuclease. The Mlh1-Pms1 interface mutants tested were largely proficient for endonuclease activity.
