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. 2022 Oct 24;12:973223. doi: 10.3389/fonc.2022.973223

Table 2.

Multivariate analysis results concerning FFLR, CFS, FFS, FFDM, and OS.

Variable FFLR CFS FFS FFDM OS
Adj O.R. 95% C.I. p Adj O.R. 95% C.I. p Adj O.R. 95% C.I. p Adj O.R. 95% C.I. p Adj O.R. 95% C.I. p
Male sex 3.5 1.7–7.1 <0.001 5.5 2–15.1 0.001 2.1 1.01–4.5 0,045 2.4 1.2–4.9 0,015 NS
True squamous cell carcinoma 1.4 1.1–2.0 0.036 1.36 1.1–2.2 0.033 NS NS NS
Tumor fistulization 4.5 1.5–13.4 0.006 9.8 2–48.4 0.005 NS NS NS
N+ NS NS NS 4.9 2–12.2 0,001 NS
High stage group 2.56 1.3–4.9 0.006 NS NS NS
HIV + NS NS NS NS NS
CDDP-5FU cht NS NS NS NS NS
Split course schedule NS NS NS NS NS
Cht compliance NS 5.3 1.8–17 0.003 NS NS NS
Unplanned treatment interruption 6.2 2.1–17.9 0.001 80 6.7–950 NS NS NS
2D vs 3D IGRT 4.5 1.9–10.4 0.001 4.1 1.1–14.9 0.031 NS NS 5.6 1.7–18.1 0.01–2
3DCRT vs IMRT NS 3.1 0.96–9.9 0.059 NS NS 6.6 1.5–29.1 0.004

3DCRT, 3D conformal radiotherapy; IMRT, intensity modulated radiotherapy; V-MAT, volumetric-modulated ARC therapy; IGRT, image-guided radiotherapy; N+, positive nodes; HIV+, HIV positive; NS, not statistically signficant.