Table 2:
Univariate analyses for the association between IBD and health morbidities within the MarketScan Cohort
| Variable | IBD N=80,907 |
Control§ N=404,535 |
OR | 95% Lower CI |
95% Upper CI |
Adjusted * p- Value** |
||
|---|---|---|---|---|---|---|---|---|
| n | % | n | % | |||||
| Clostridiodes difficile | 2888 | 3.6 | 785 | 0.2 | 19.4 | 17.9 | 21 | 0.0001 |
| Erythema nodosum | 479 | 0.6 | 157 | 0 | 15.4 | 12.8 | 18.4 | 0.0001 |
| CMV | 254 | 0.3 | 112 | 0 | 11.4 | 9.1 | 14.2 | 0.0001 |
| Parametritis | 376 | 0.5 | 181 | 0 | 10.5 | 8.8 | 12.5 | 0.0001 |
| Pyoderma | 607 | 0.8 | 492 | 0.1 | 6.2 | 5.5 | 7 | 0.0001 |
| Klebsiella | 209 | 0.3 | 204 | 0.1 | 5.1 | 4.2 | 6.2 | 0.0001 |
| Pernicious anemia | 1893 | 2.3 | 2077 | 0.5 | 4.7 | 4.4 | 5 | 0.0001 |
| IVC Thrombosis | 68 | 0.1 | 76 | 0 | 4.5 | 3.2 | 6.2 | 0.0001 |
| Gastroparesis | 678 | 0.8 | 881 | 0.2 | 3.9 | 3.5 | 4.3 | 0.0001 |
| Autoimmune hemolytic anemia | 79 | 0.1 | 101 | 0 | 3.9 | 2.9 | 5.3 | 0.0001 |
| Endocarditis | 113 | 0.1 | 159 | 0 | 3.6 | 2.8 | 4.5 | 0.0001 |
| Escherichia coli | 289 | 0.4 | 425 | 0.1 | 3.4 | 2.9 | 4 | 0.0001 |
| Pseudomonas | 162 | 0.2 | 244 | 0.1 | 3.3 | 2.7 | 4.1 | 0.0001 |
| Thrombosis-all | 2807 | 3.5 | 4745 | 1.2 | 3.1 | 2.9 | 3.2 | 0.0001 |
| Mycosis | 233 | 0.3 | 379 | 0.1 | 3.1 | 2.6 | 3.6 | 0.0001 |
| Spontaneous tension pneumothorax | 37 | 0.1 | 61 | 0.0 | 3.03 | 2.02 | 4.56 | 0.0001 |
| Acute embolism of lower extremity | 1843 | 2.3 | 3110 | 0.8 | 3 | 2.9 | 3.2 | 0.0001 |
| Wegener's | 42 | 0.1 | 72 | 0 | 2.9 | 2 | 4.3 | 0.0001 |
| Staphylococcus | 309 | 0.4 | 564 | 0.1 | 2.7 | 2.4 | 3.2 | 0.0001 |
| Pulmonary collapse | 3542 | 4.4 | 6904 | 1.7 | 2.7 | 2.6 | 2.8 | 0.0001 |
| Bartholin gland cyst | 184 | 0.2 | 370 | 0.1 | 2.5 | 2.1 | 3 | 0.0001 |
| Pleurisy | 33 | 0 | 75 | 0 | 2.2 | 1.5 | 3.3 | 0.0001 |
| Pericarditis | 471 | 0.6 | 1146 | 0.3 | 2.1 | 1.9 | 2.3 | 0.0001 |
| Pulmonary fibrosis | 931 | 1.2 | 2390 | 0.6 | 2 | 1.8 | 2.1 | 0.0001 |
| Genitourinary □ | 1370 | 1.7 | 3625 | 0.9 | 1.9 | 1.8 | 2 | 0.0001 |
| Raynaud’s | 480 | 0.6 | 1248 | 0.3 | 1.9 | 1.7 | 2.1 | 0.0001 |
| Pneumonia | 5234 | 6.5 | 14159 | 3.5 | 1.9 | 1.9 | 2 | 0.0001 |
| Cardiac dysrhythmias | 9965 | 12.3 | 30701 | 7.6 | 1.8 | 1.8 | 1.8 | 0.0001 |
| Migraine | 4017 | 5 | 12118 | 3 | 1.7 | 1.6 | 1.8 | 0.0001 |
| Emphysema | 958 | 1.2 | 2837 | 0.7 | 1.7 | 1.6 | 1.8 | 0.0001 |
| Parkinson’s disease | 1919 | 2.37 | 5869 | 1.45 | 1.7 | 1.6 | 1.7 | 0.0001 |
| Mononeuritis | 1650 | 2 | 5092 | 1.3 | 1.6 | 1.5 | 1.7 | 0.0001 |
| LBBB | 148 | 0.2 | 457 | 0.1 | 1.6 | 1.3 | 2 | 0.0001 |
| RBBB | 570 | 0.7 | 1881 | 0.5 | 1.5 | 1.4 | 1.7 | 0.0001 |
| Conduction disorders | 1851 | 2.3 | 6296 | 1.6 | 1.5 | 1.4 | 1.6 | 0.0001 |
| Orchitis | 505 | 0.6 | 1857 | 0.5 | 1.4 | 1.2 | 1.5 | 0.0001 |
| Pharyngitis | 15128 | 18.7 | 57635 | 14.2 | 1.4 | 1.4 | 1.4 | 0.0001 |
| Urethritis | 320 | 0.4 | 1266 | 0.3 | 1.3 | 1.1 | 1.4 | 0.0002 |
| Tracheitis | 92 | 0.1 | 341 | 0.1 | 1.3 | 1.1 | 1.7 | 0.0105 |
| Peripheral vascular disease | 2136 | 2.6 | 8201 | 2 | 1.3 | 1.3 | 1.4 | 0.0001 |
| Acute tonsillitis | 1450 | 1.8 | 6535 | 1.6 | 1.1 | 1.1 | 1.2 | 0.0003 |
§
1-to-5 matching in age and gender.
*
adjusted p-values with the False Discovery Rate (FDR) method
**
Based on the Cochran-Mantel-Haenszel test
□
Including parametritis, urethritis, orchitis, and Bartholin gland cyst.
IVC: Inferior vena cava; RBBB: Right bundle branch block; LBBB: Left bundle branch block; CMV: cytomegalovirus.