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. Author manuscript; available in PMC: 2022 Nov 7.
Published in final edited form as: Prostate. 2019 Aug 21;79(14):1692–1704. doi: 10.1002/pros.23894

FIGURE 2.

FIGURE 2

A, Profile showing fold change in Wnt gene expression in probasin/TAg rat VPs at 25 weeks of age relative to WT prostates (SV40/WT) using a rat Wnt polymerase chain reaction array. Fold change in blue indicates a decrease and fold change in black is an increase relative expression levels. N = 3. B, Histology, Ki67 and WNT10B immunostaining in WT and probasin/Tag VPs at 25 weeks. (Top) WT VPs show normal glandular histology by hematoxylin and eosin stain, scarce proliferation by Ki67 labeling, and epithelial WNT10B immunostain. (Bottom) The probasin/Tag VP has widespread poorly differentiated adenocarcinoma (arrowheads), robust proliferation by Ki67 labeling, and marked reduction in epithelial WNT10B protein. Scale bar = 50 μM. VP, ventral prostate; WT, Wild type