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. 2022 Oct 24;13:998262. doi: 10.3389/fimmu.2022.998262

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Copyright © 2022 Stolfi, Castiglione, Mastrostefano, Di Biase, Di Biase, Palmieri and Prisco

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Principal Component Analysis of the correlation between pre-existing immunological memory at t₁ and the peak value of the antibody response to the second dose. (A) The dot plot shows PC1 and PC2 in individuals in treatment groups 1A, 1B and 1C. PC2 separates the different dosing protocols. (B) Loadings of PC1 and PC2. In PC2, Tc has the highest loading.